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Parker Garcia
Parker Garcia

Mature Jan Burton

Looking for a MILFy British slag who's got a nasty streak longer than the list of scenes you've probably already wanked to on this site? We've got just the one for you. Her name is Jan Burton, and we'd be damned if she ain't the real, authentic thing. This isn't some pro porno slut posing as a hot Mary Poppins type as part of her angle. Jan is 100% authentic in her mature looks and demeanor. From her lady-like appearance, to her humid and hairy, bushy twat, and her tight body, Jan's looks are perfect for your penile pleasure. OK, maybe she did enhance her tits a bit, from natural B's to Elegant E's, but we'll gladly forgive her for sporting those. Coming from Ashford, England, Jan's husband suggested they set up a webcam service since he was so damn proud of his wife's hotness. Being a slut and an exhibitionist, Jan gladly agreed, and soon, their site was blowing up the cam charts. She loves the taste of cock and the feeling of thick, long schlongs reaching the back depths of her oral hole. While she loves her husband, she also craves an occasional face-full of vagina. She and her hubbie are open, so they often bring others around - both guys and gals - for Jan to suck, lap, and fuck to her heart's delight. PornPornPorn has just begun collecting Jan's filthy videos, but we're already plenty happy with their scandalous and salacious quality.

mature jan burton

Prices are $16 for general public, $14 for senior citizens and SUNY faculty and staff and $7 for all students. Because of the subject matter and the graphic violence involved in the tale of Sweeney Todd, the musical is recommended for mature audiences only.

Tumors frequently induce the multifunctional cytokine IL-6, which has been linked to several paraneoplastic syndromes, most notably cachexia. IL-6 stimulates osteoclast formation, causes mild hypercalcemia, and is produced by bone cells in vitro upon exposure to systemic hormones. Since IL-6 is produced together with parathyroid hormone-related protein (PTH-rP) in some patients with cancer, we tested the hypothesis that production of IL-6 potentiates the effects of PTH-rP on Ca2+ homeostasis and osteoclastic bone resorption and examined potential mechanisms for these interactions in vivo. Chinese hamster ovarian (CHO) cells stably transfected with cDNAs for IL-6 (CHO/IL-6) and PTH-rP sense (CHO/PTH-rP) or antisense (CHO/PTH-rP AS) were inoculated intramuscularly into nude mice. Experimental groups included CHO/IL-6 plus CHO/PTH-rP; CHO/IL-6 plus CHO/PTH-rP AS; CHO/IL-6 alone; and CHO/PTH-rP alone. Blood ionized Ca2+ was measured on days 0, 7, 10, 12, and 13. Three different developmental stages in the osteoclast lineage were examined at day 13: the early multipotential precursor, granulocyte macrophage colony-forming units (CFU-GM); more mature mononuclear osteoclast precursors, assessed by their capacity to form tartrate-resistant acid phosphatase-positive multinucleated cells in marrow cultures; and mature osteoclasts, assessed by histomorphometry. IL-6 increased CFU-GM but not bone resorption or Ca2+. In contrast, PTH-rP induced hypercalcemia and bone resorption and increased multinucleated osteoclasts and more mature precursors cells, but not CFU-GM. However, mice treated with both IL-6 and PTH-rP had very marked hypercalcemia and osteoclastosis as well as an increase in the number of both CFU-GM and mature osteoclast precursors. These data demonstrate that IL-6 enhances PTH-rP-mediated hypercalcemia and bone resorption, most likely by increasing the pool of early osteoclast precursors that in turn can differentiate to mature osteoclasts. We conclude that IL-6 stimulatory effects on osteoclast precursors may enhance the effects of other bone resorption factors that act at later stages in the osteoclast lineage. 041b061a72




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